Depakote (Valproate)
Depakote is a mood stabiliser effective for both the manic and depressive phases of bipolar disorder. It has a long history of use in neurology and psychiatry and is also prescribed for epilepsy and migraine prevention.
Most patients pay less than $20 per appointment.
Depakote works by increasing levels of GABA — a calming neurotransmitter — in the brain. Its active ingredient, valproate, is particularly strong for treating acute mania and preventing future episodes, though it carries important risks, especially for people who may become pregnant.
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Komal is an LGBTQ+ affirming psychiatrist who works with queer, trans, and gender-expansive adolescents and adults navigating anxiety, depression, ADHD, trauma, and identity. She offers a space where your full self is welcome, and brings real understanding to the intersection of queerness, culture, and mental health.
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Adam Butera
Adam is an LGBTQ+ affirming psychiatrist with 23 years in private practice, offering care for depression, bipolar disorder, anxiety, PTSD, OCD, addiction, and ADHD. He takes time to understand each person as a whole human being, working with adolescents, adults, and seniors across diverse backgrounds.
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Depakote (valproate) is FDA-approved for bipolar disorder (manic episodes), epilepsy, and migraine prevention. It is also commonly used off-label for other seizure disorders.
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Depakote carries a significant risk of birth defects and developmental problems in babies exposed in utero. It should not be used by people who may become pregnant without a thorough risk discussion with their doctor.
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Weight gain, tremor, hair loss, nausea, and fatigue are the most common. Liver function and platelet counts should be monitored regularly.
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Depakote is metabolised by the liver and can, rarely, cause liver damage. Routine liver function tests are part of safe monitoring.
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Yes — weight gain is one of the most common concerns with Depakote. Diet and activity adjustments may help, and your psychiatrist can discuss alternatives if this becomes a significant problem.
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Depakote works relatively quickly — significant improvement in acute mania is often seen within 1–2 weeks, which makes it useful in acute settings.
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No — alcohol significantly increases the risk of liver damage and can worsen side effects. Avoid alcohol while on Depakote.
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Book a free consult at Outspace. Our psychiatrists will assess whether Depakote is appropriate and discuss all risks and monitoring requirements with you.